CUVAF · Optical biomarker

The light your
eyes remember.

OLUX non-invasively quantifies conjunctival ultraviolet autofluorescence, an objective biomarker of accumulated sun exposure and a predictor of the risk of myopic progression in childhood.

Clinical system · v0.5
OLUX device, front view

Every hour in the sun leaves a fingerprint on the conjunctiva. For the first time, that fingerprint can be measured.

— 01 / Product

Designed to see everything,
without touching the eye.

An ergonomic binocular headpiece that adapts its illumination to the conjunctiva and captures the CUVAF area at clinical resolution. Built for pediatric and in-office use.

OLUX device in 3/4 view with its top controls
OLUX · One

Clinical capture of the CUVAF area in a single pass.

Controlled UV-A illumination, a calibrated binocular sensor, and automatic processing. No dilation, no contact, no contrast dye.

OLUX device seen from a top angle with its central control
Illumination · 365 nm

Integrated UV-A ring to excite conjunctival autofluorescence.

Side view of the OLUX device
Design

Pediatric ergonomics.

Top view of the OLUX device and its USB-C port
Connectivity

USB-C.

— 02 / Technology

Three steps. One biomarker.

The device illuminates the conjunctiva with narrow-band ultraviolet light. Tissue that has been exposed to the sun fluoresces. The camera measures the area and the system delivers a reproducible CUVAF index.

01·UV

Controlled UV-A illumination.

A ring of LEDs at 365 nm excites the autofluorescence of the conjunctiva with no dilation or contact. Optical dose certified for ophthalmic use, including pediatric.

02·CV

Conjunctival capture and segmentation.

A calibrated binocular sensor records the fluorescence. Computer vision models delineate the CUVAF area with sub-pixel precision, reproducibly across observers.

03·DX

Longitudinal clinical index.

The quantified area is translated into a CUVAF index, comparable against age-based norms and trackable over time. The clinic gains an objective metric of myopia risk.

— 03 / Application

For the eyes that are still growing.

Childhood myopia is a silent pandemic. Scientific evidence links a lack of daytime exposure to its progression. OLUX delivers an objective metric where before there were only questionnaires.

Pilot study · Pediatrics Child wearing the OLUX device The OLUX device turns translucent and reveals the UV-A illuminators exciting the child's conjunctiva

An optical fingerprint to assess outdoor life.

The CUVAF area reflects accumulated exposure to visible and UV sunlight over recent months. It's the first objective biomarker able to complement patient history and refraction in the pediatric ophthalmology clinic.

+30%
Children with myopia in Europe
35min
Average daily time outdoors
2027
WHO prevalence projection
0.85+
Inter-observer agreement
— 04 / Biomarker

More sun, more fingerprint.

The CUVAF area is invisible to the naked eye. Under natural light, two eyes can look identical; under UV-A they reveal how much sunlight the conjunctiva has received in recent months. Hover over each eye to see its fingerprint.

Indoors · low exposure Natural light UV-A · 365 nm Eye lit in low light, no visible fluorescence The same eye under UV-A: small area of conjunctival fluorescence
Subtle fingerprint.
Less time outdoors.
0.2mm² CUVAF
Outdoors · high exposure Natural light UV-A · 365 nm Eye under natural light, no visible fluorescence The same eye under UV-A: broad area of conjunctival fluorescence
Broad fingerprint.
An outdoor life.
8.1mm² CUVAF
Lower exposure Higher exposure · larger CUVAF area
— 06 / Team

Research, optics, and engineering.

OLUX was born at the University of Navarra Clinic, the result of collaboration between ophthalmologists, engineers, and product designers.

Dr. Sergio Recalde Maestre
RESEARCHER

Dr. Sergio Recalde Maestre

Scientific direction of the project and the CUVAF research line.

Dr. Jorge González Zamora
Ophthalmologist · Researcher

Dr. Jorge González Zamora

Specialist in retinal pathology and co-investigator of the project.

Gorka Oroz Laurenz
INDUSTRIAL DESIGN ENGINEER

Gorka Oroz Laurenz

Design, development, and prototyping of the OLUX device.

Nicolás López Aguileta Castaño
Biomedical engineering · AI

Nicolás López Aguileta Castaño

Design of the artificial-intelligence software for CUVAF area segmentation.

Designed for the ophthalmology clinic.

OLUX lets you quantify patients' sun exposure and assess the risk of myopic progression. Access restricted to healthcare professionals.

Request access Restricted access · professionals